Study Design in Etiologic Research
This course is a core component of any Master´s degree in Epidemiology and is also key to being able to follow specialized online medical courses in epidemiology. Its aim is for you to learn about the principles and practice of cohort, case-control and cross-sectional studies. We will discuss design, data collection, and outcome measures, as well as the major advantages and disadvantages of the different study designs. The emphasis will be on the application of study design in etiologic research. This online health course focuses on the more classical approach but also addresses modern concepts and design options, such as case-cohort designs. Various other study designs will also be discussed, with an emphasis on validity issues. Study Design in Etiologic Research is part of MSc Epidemiology Postgraduate Online; the online MSc program in Epidemiology offered by Utrecht University, University Medical Center Utrecht, MSc Epidemiology and Elevate.
By the end of the course, you should be able to:
- Explain the principles, design and validity aspects of a cohort study, a case-control study, and a cross-sectional study
- Interpret the measures of frequency and association from cohort, case-control, and cross-sectional studies
In particular, you should be able to:
- Calculate the corresponding measures of frequency and association and explain these calculations
- Explain the modern designs used instead of the classical case-control study (e.g. case-cohort study or case-crossover study)
- Explain the methods of data collection in the different study designs
- Explain the specific aspects of study design in veterinary epidemiology as compared to human epidemiology (e.g. clustering of animals and the effects this has on study design, measurement of exposure status, disease status and confounders, and the selection of the study population)
- Appraise scientific abstracts and papers on the choice of study design and debate the relevant validity aspects
- Design an appropriate study to be used in a specific situation or to answer an etiologic study question
- Design of cohort, case-control and cross-sectional studies
- Data collection of the above studies
- Outcome measures of the above studies
- Advantages and disadvantages of the above studies
The whole course will take place online, apart from the final exam. The following learning methods will be used:
- Web lectures
- Group discussions
- Group assignments
Sunday before start date - introduce yourself
Sunday – complete Learning Unit 1-3
Sunday – complete Learning Unit 4-6
Sunday – complete Learning Unit 7-8
Sunday – complete Learning Unit 9-11
Monday – start preparing the writing of a study proposal
Sunday – complete Learning Unit 12
Monday – submission of the study proposal
Wednesday – review of all other study proposals submitted by peers
Sunday – complete Learning Unit 13
Monday – Final Exam
This course includes an exam with essay questions, which is the only part of the course that is not online. You can find more information about the examination on the Elevate website.
If you are able and willing to take the exam in Utrecht, the Netherlands, we are available to proctor the exam for you without any costs. If you have to take the exam from a different location, you need a proctor.
This proctor may ask you to pay for their expenses. Please read more about proctoring on our specific webpage. The exam is not compulsory. However, if you want to receive the Course Certificate and the credits, it is obligatory to take the exam. You are allowed to redo the exam once.
As this is a university course, it is covered by academic accreditation. Upon successful completion of this course, you will receive a recognized certificate from Utrecht University and the UMC Utrecht.
To enroll in this course, you need:
- A Bachelor’s degree in (bio)medical education or a degree in epidemiology or related subject
- Sufficient proficiency in English reading and writing
Compulsory study materials:
‘Clinical Epidemiology – Principles, Methods and Applications for Clinical Research’ by D.E. Grobbee & A.W. Hoes, Jones and Bartlett Publishers, 2014, ISBN-13: 978-1449674328.
As this is an online course, you do need access to an internet connection in order to be able to follow lectures, complete assignments and communicate with fellow participants.
Course is offered by As part of the following program: