Knowledge economy, as was defined by Peter Drucker and others, poses unprecedented challenges for companies and organizations. One of the pillars on which business models are based on this new era is innovation, a complex and multidimensional phenomenon. From this perspective, strategic management of innovation resulting in the ability of the company to build a culture of innovation that can generate value reinventing regularly its own business model, adapting to the constantly changing environment and introducing innovations incremental order , developmental and / or disruptive. It is the responsibility of driving teams create the internal conditions for these policies - the result of a Vision and Mission consensus - are properly understood and internalized through appropriate communication processes. Innovations can occur in multiple stages inside and outside the company (Doblin model). This is a proposal theoretical-practical oriented development of generic and systemic skills in order to integrate innovation in organizational culture as a strategic axis for value creation in business models and policies for development and growth companies and organizations.... [-]